Total loans rose 7%, but the provision for loan losses jumped 27% to $1.7 billion.
Increases in commercial real estate, C&I and municipal and state loans boosted fourth-quarter profit at the $13 billion-asset Trustmark.
Fifth Third and other regionals have ditched what they deem to be high-risk commercial loans in hopes of strengthening credit quality over the long term.
Cost control and improved credit were overshadowed by a big charge tied to a dispute with the FDIC.
Profits at the Midwestern bank fell on lower adjusted noninterest income and loans and on a one-time item.
Net income was also aided by a sharp drop in the provision for credit losses as chargeoffs on energy loans continued to decline.
Expanded lending across a broad range of categories and extremely low unemployment in Hawaii pushed up the Honolulu bank's quarterly profit.
The Stamford, Conn., credit card issuer reported net income of $576 million, up 5.3% from the same period a year earlier.
Quarterly profit fell at SunTrust Banks in Atlanta as noninterest expense rose 8.4% and its loan-loss provision increased.
Quarterly profit improved despite a spike in noninterest expenses.